Endocrine Abstracts

Introduction: Serum IGF1 levels declined particularly with hyperglycemia in diabetic patients and lower IGF1 levels has been suggested to be associated with the development of diabetes. IGF1 levels appear to increase with the improvement in glycemic control in diabetic patients but do not reach normal levels. Also, it affected by gender; in this study we aimed to investigate effects of gender on IGF1 changes with basal insulin analogs.Methods: The serum ...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy associated with increased cardiovascular risk in reproductive aged women. Circulating osteoprotegerin (OPG) and soluble receptor activator of nuclear factor κB ligand (sRANKL) are associated with subclinical atherosclerosis. Our aim is to evalutate serum OPG and sRANKL levels and their relations with cardiovascular and metabolic markers in paients with obese and non-obese PCOS.<p class="abstext"...

Background: Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is a heterogeneous that cannot be definitively diagnosed as benign, malignancy-suspect, or malignant. The estimated risk of AUS/FLUS malignancy is reported 5% to 15% according to the Bethesda System (BS). This study was conducted to evaluate the ability of mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) to predict the malignant potential of nodules diag...

Background: Primary hyperparathyroidism (PHPT), caused by increased parathyroid hormone (PTH) secretion, leads to generalised disorder of bone metabolism characterised with hypercalcaemia and hypophosphatemia. Causes of PHPT include solitary parathyroid adenoma (80%), primary parathyroid hyperplasia (10–15%), and parathyroid carcinoma (1–2%). Other rare cause is double parathyroid adenomas (DPA) with frequency <1–2%, which can be sporadic or familial. DPA sh...

Aim: To evaluate serum and intranodular vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-1 (VEGFR-1) level thyroid nodules and explore its relevance to ultrasound feature/pathological results.Methods: A total of 80 patients (62 women and 18 men) with thyroid nodules were included in this prospective study. Thyroid function tests, fine needle aspiration biopsies, ultrasonographic and scintigraphic evaluation were r...

Introduction: Multiple endocrine neoplasia type 2A (MEN2A) is a complex autosomal dominant inherited syndrome characterized by medullary thyroid carcinoma (MTC), phaeochromocytoma, and primary parathyroid hyperplasia (PPH). In patients with only one or two clinical features, identification of a germline rearranged in transfection (RET) mutation or the identification of the clinical features of MEN2A in other first degree relatives is required to make the diagnosis. We present ...

Introduction: Non-typhoid salmonella as the causative agent of acute bacterial thyroiditis is rarely reported. We report a case with suppurative thyroiditis caused by salmonella infection.Case report: Fifty-year old woman had fewer and recurrent pain with swelling in the left region of the neck. Physical examination revealed the weight 78 kg, the height 167 cm, blood pressure 100/70 mmHg, pulse 78/min, the body temperature 37.6 degrees. Thyroid gland was...

Aim: To determine how serum procalcitonin (PCT) levels are affected in diabetic and diabetic nephropathic patients, it is important to determine whether PCT is indicative of an inflammation in these patients.Materials and methods: The study included 175 patients (75 diabetic nephropathy (group 1), 75 diabetic (group 2) and 25 non-diabetic nephropathy (group 3)) and 75 healthy volunteers. Serum and urine creatinine, serum high sensitive C- reactive protei...

Central nervous system involvement is observed in 5-14% of Behçet’s disease and this form is called neurobehçet syndrome (NBS). There are two main forms of CNS involvement in Neurobehçet syndrome, in which parenchymal involvement and vascular involvement are prominent. Cerebral venous thrombosis (CVT), the most prominent form of vascular involvement, has been reported in 8% in Behçet’s disease and in approximately 18% in NBS. Although CVT is the m...

Introduction: Primary hyperparathyroidism is commonly treated with targeted parathyroidectomy guided by preoperative imaging and intraoperative parathormone monitoring. Despite advanced imaging techniques, failure of parathyroid localization still occurs. Hyperparathyroidism-jaw tumor syndrome and familial isolated hyperparathyroidism are a rare autosomal dominant tumor syndrome characterized by hyperparathyroidism. In this report, we present four patients with familial isolat...